Publications

Oncology

  1. Angamuthu, Venkatachalam, et al. “Pharmacological activities of antroquinonol-Mini review.” Chemico-biological interactions 297 (2019): 8-15.
  2. Ho, Ching-Liang, et al. “Phase II multicenter study of antroquinonol in patients with stage IV non-small cell lung cancer who have failed at least two lines of anti-cancer therapy.” (2019): e20522-e20522.
  3. Lin, Hsien-Chun, et al. “Antroquinonol, a ubiquinone derivative from the mushroom Antrodia camphorata, inhibits colon cancer stem cell-like properties: insights into the molecular mechanism and inhibitory targets.” Journal of agricultural and food chemistry 65.1 (2016): 51-59.
  4. Ho, Ching-Liang, et al. “Antroquinonol to block Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells.” (2015): e18526-e18526.
  5. Lee, Wai-Theng, et al. “Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1-and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.” Food and chemical toxicology 78 (2015): 33-41.
  6. Lee, Yu-Chin, et al. “A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.” Molecular and clinical oncology 3.6 (2015): 1375-1380.
  7. Thiyagarajan, Varadharajan, May-Jywan Tsai, and Ching-Feng Weng. “Antroquinonol targets FAK-signaling pathway suppressed cell migration, invasion, and tumor growth of C6 glioma.” PLoS One 10.10 (2015): e0141285.
  8. Ho, Ching-Liang, et al. “Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells.” Biomedicine & Pharmacotherapy 68.8 (2014): 1007-1014.
  9. Yu, Chia-Chun, et al. “Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.” The Journal of nutritional biochemistry 23.8 (2012): 900-907.
  10. Kumar, V. Bharath, et al. “Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles.” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 707.1-2 (2011): 42-52.
  11. Chiang, Po-Cheng, et al. “Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.” Biochemical pharmacology 79.2 (2010): 162-171.
  12. Hsieh, Wan-Yu, et al. “Abstract# 3676: Antroquinonol inhibits tumorgenesis and metastasis in highly invasive non-small-cell lung cancer cells.” (2009): 3676-3676.

Neurodegenerative Disease

  1. Chang, Wen-Han, Miles C. Chen, and Irene H. Cheng. “Antroquinonol lowers brain amyloid-β levels and improves spatial learning and memory in a transgenic mouse model of Alzheimer’s disease.” Scientific reports 5 (2015): 15067.

Autoimmune disease

  1. Guan, Cuiping, et al. “Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2.” Oxidative medicine and cellular longevity 2017 (2017).
  2. Yang, Shun-Min, et al. “Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome.” Free Radical Biology and Medicine 61 (2013): 285-297.
  3. Tsai, Pei‐Yi, et al. “Antroquinonol differentially modulates T cell activity and reduces interleukin‐18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis.” Arthritis & Rheumatism 64.1 (2012): 232-242.
  4. Chang, Jia-Ming, et al. “An extract of Antrodia camphorata mycelia attenuates the progression of nephritis in systemic lupus erythematosus-prone NZB/W F1 mice.” Evidence-Based Complementary and Alternative Medicine 2011 (2011).
  5. Kumar, KJ Senthil, et al. “Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.” Journal of ethnopharmacology 136.1 (2011): 168-177.
  6. Kumar, KJ Senthil, et al. “Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.” Journal of ethnopharmacology 136.1 (2011): 168-177.

Metabolic Syndrome

  1. Chen, Jiun‐Rong, et al. “Antroquinonol Attenuated Abdominal and Hepatic Fat Accumulation in Rats Fed an Obesogenic Diet.” Journal of food science 84.9 (2019): 2682-2687.
  2. Chen, Jiun-Rong, et al. “Renoprotective effects of antroquinonol in rats with Nω-nitro-L-arginine methyl ester-induced hypertension.” Nutrients 10.10 (2018): 1521.
  3. Chena, Miles Chih-Ming, et al. “Effects of Antrodia Camphorata Mycelia Extract Containing Antroquinonol on Lowering Low-Density Lipoprotein Cholesterol: A Randomized Double-Blind Study.” Journal of Pharmacy and Nutrition Sciences 7 (2017): 73-80.
  4. Hsu, C. Y., et al. “Synthetic (+)‐antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities.” British journal of pharmacology 172.1 (2015): 38-49.
  5. Lin, Tsai-Jung, et al. “Antroquinonol, an active pure compound from Antrodia camphorate mycelium, modulates the development of atherosclerosis in a mouse carotid artery ligation model.” Journal of Medical Sciences 34.2 (2014): 56.

Anti-fatigue, liver protection

  1. Kumar, KJ Senthil, et al. “Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.” Journal of ethnopharmacology 136.1 (2011): 168-177.
  2. “The Anti-exhaustive Effects of Antroquinonol in Tennis Player.” In The 9th Annual Conference for SCSEPF. 2010.
  3. “The effects of Antroquinonol supplementation on physiological responses after exhaustive tennis groundstrokes.” In The 9th Annual Conference for SCSEPF. 2010.

Synthesis

[Publications]

  1. Chou, Kevin Chi-Chung, et al. “4-Hydroxybenzoic acid serves as an endogenous ring precursor for antroquinonol biosynthesis in Antrodia cinnamomea.” Phytochemistry 161 (2019): 97-106.
  2. Wang, Xiaoming, et al. “Total synthesis of (±)-antroquinonol.” Organic & biomolecular chemistry 17.7 (2019): 1754-1757.
  3. Xia, Yongjun, et al. “Induction of antroquinonol production by addition of hydrogen peroxide in the fermentation of Antrodia camphorata S‐29.” Journal of the Science of Food and Agriculture 97.2 (2017): 595-599.
  4. Hsu, Che‐Sheng, and Jim‐Min Fang. “Synthesis of (+)‐Antroquinonol and Analogues by Using Enantioselective Michael Reactions of Benzoquinone Monoketals.” European Journal of Organic Chemistry 2016.22 (2016): 3809-3816.
  5. Hu, Yong-Dan, et al. “A mechanistic study on the biosynthetic regulation of bioactive metabolite antroquinonol from edible and medicinal mushroom Antrodia camphorata.” Journal of Functional Foods 25 (2016): 70-79.
  6. Lu Ruiqiu, Zhang Bobo, and Xu Ganrong. Recovery and Purification of Antroquinonol from Antrodia Camphorata Fermentation Products.” Journal of Food Science and Biotechnology, vol. 35, no. 5, 2016, pp. 549–555.
  7. Hsu, Che-Sheng, Ho-Hsuan Chou, and Jim-Min Fang. “A short synthesis of (±)-antroquinonol in an unusual scaffold of 4-hydroxy-2-cyclohexenone.” Organic & biomolecular chemistry 13.19 (2015): 5510-5519.
  8. Modugu, Nagi Reddy, and Goverdhan Mehta. “An approach toward novel bioactive natural products antroquinonols: de novo construction of the carbocyclic core.” Tetrahedron Letters 56.44 (2015): 6030-6033.
  9. Sulake, Rohidas S., and Chinpiao Chen. “Total synthesis of (+)-antroquinonol and (+)-antroquinonol D.” Organic letters 17.5 (2015): 1138-1141.
  10. Sulake, Rohidas S., et al. “Synthesis of (+)-antroquinonol: an antihyperglycemic agent.” The Journal of organic chemistry 80.12 (2015): 6044-6051.
  11. Chen, Chien-Kuang, et al. “Metabolites of antroquinonol found in rat urine following oral administration.” Journal of natural products 77.4 (2014): 1061-1064.
  12. Hu, Yong-Dan, et al. “Enabling the biosynthesis of antroquinonol in submerged fermentation of Antrodia camphorata.” Biochemical engineering journal 91 (2014): 157-162.
  13. YU, Xue-chun, et al. “Research of A. camphorata solid-state fermentation production Antroquinonol and extraction Antroquinonl.” Science and Technology of Food Industry 5 (2013): 035.