Publications
Oncology
- Angamuthu, Venkatachalam, et al. “Pharmacological activities of antroquinonol-Mini review.” Chemico-biological interactions 297 (2019): 8-15.
- ASCO Meeting 2019 , Abstract e20522,” Phase II multicenter study of antroquinonol in patients with stage IV non-small cell lung cancer who have failed at least two lines of anti-cancer therapy.”
- Ho,Ching-Liang, David S. Ettinger, et al. “ Phase II multicenter study of antroquinonol in patients with stage IV non-small cell lung cancer.”, Journal of Clinical Oncology, 10.1200/JCO.2019.37.15_suppl.e20522
- Lin, Hsien-Chun, et al. “Antroquinonol, a ubiquinone derivative from the mushroom Antrodia camphorata, inhibits colon cancer stem cell-like properties: insights into the molecular mechanism and inhibitory targets.” Journal of agricultural and food chemistry 65.1 (2016): 51-59.
- Ho, Ching-Liang, et al. “Antroquinonol to block Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells.” (2015): e18526-e18526.
- Lee, Wai-Theng, et al. “Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1-and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.” Food and chemical toxicology 78 (2015): 33-41.
- Lee, Yu-Chin, et al. “A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.” Molecular and clinical oncology 3.6 (2015): 1375-1380.
- Thiyagarajan, Varadharajan, May-Jywan Tsai, and Ching-Feng Weng. “Antroquinonol targets FAK-signaling pathway suppressed cell migration, invasion, and tumor growth of C6 glioma.” PLoS One 10.10 (2015): e0141285.
- Ho, Ching-Liang, et al. “Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells.” Biomedicine & Pharmacotherapy 68.8 (2014): 1007-1014.
- Yu, Chia-Chun, et al. “Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.” The Journal of nutritional biochemistry 23.8 (2012): 900-907.
- Kumar, V. Bharath, et al. “Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles.” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 707.1-2 (2011): 42-52.
- Chiang, Po-Cheng, et al. “Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.” Biochemical pharmacology 79.2 (2010): 162-171.
- Hsieh, Wan-Yu, et al. “Abstract# 3676: Antroquinonol inhibits tumorgenesis and metastasis in highly invasive non-small-cell lung cancer cells.” (2009): 3676-3676.
- Yang, SS et.al. “New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata.”, Planta Med. 2009 Apr;75(5):512-6. doi: 10.1055/s-0029-1185305.
Neurodegenerative Disease
- Chang, Wen-Han, Miles C. Chen, and Irene H. Cheng. “Antroquinonol lowers brain amyloid-β levels and improves spatial learning and memory in a transgenic mouse model of Alzheimer’s disease.” Scientific reports 5 (2015): 15067.
Autoimmune disease
- Guan, Cuiping, et al. “Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2.” Oxidative medicine and cellular longevity 2017 (2017).
- Yang, Shun-Min, et al. “Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome.” Free Radical Biology and Medicine 61 (2013): 285-297.
- Tsai, Pei‐Yi, et al. “Antroquinonol differentially modulates T cell activity and reduces interleukin‐18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis.” Arthritis & Rheumatism 64.1 (2012): 232-242.
- Chang, Jia-Ming, et al. “An extract of Antrodia camphorata mycelia attenuates the progression of nephritis in systemic lupus erythematosus-prone NZB/W F1 mice.” Evidence-Based Complementary and Alternative Medicine 2011 (2011).
- Kumar, KJ Senthil, et al. “Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.” Journal of ethnopharmacology 136.1 (2011): 168-177.
- Kumar, KJ Senthil, et al. “Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.” Journal of ethnopharmacology 136.1 (2011): 168-177.
Metabolic Syndrome
- Chen, Jiun‐Rong, et al. “Antroquinonol Attenuated Abdominal and Hepatic Fat Accumulation in Rats Fed an Obesogenic Diet.” Journal of food science 84.9 (2019): 2682-2687.
- Chen, Jiun-Rong, et al. “Renoprotective effects of antroquinonol in rats with Nω-nitro-L-arginine methyl ester-induced hypertension.” Nutrients 10.10 (2018): 1521.
- Chena, Miles Chih-Ming, et al. “Effects of Antrodia Camphorata Mycelia Extract Containing Antroquinonol on Lowering Low-Density Lipoprotein Cholesterol: A Randomized Double-Blind Study.” Journal of Pharmacy and Nutrition Sciences 7 (2017): 73-80.
- Hsu, C. Y., et al. “Synthetic (+)‐antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities.” British journal of pharmacology 172.1 (2015): 38-49.
- Lin, Tsai-Jung, et al. “Antroquinonol, an active pure compound from Antrodia camphorate mycelium, modulates the development of atherosclerosis in a mouse carotid artery ligation model.” Journal of Medical Sciences 34.2 (2014): 56.
Anti-fatigue, liver protection
- Kumar, KJ Senthil, et al. “Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.” Journal of ethnopharmacology 136.1 (2011): 168-177.
- “The Anti-exhaustive Effects of Antroquinonol in Tennis Player.” In The 9th Annual Conference for SCSEPF. 2010.
- “The effects of Antroquinonol supplementation on physiological responses after exhaustive tennis groundstrokes.” In The 9th Annual Conference for SCSEPF. 2010.