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Search the name “ Antroquinonol “ or “ HOCENA” :

*Preferred Name:  Antroquinonol Capsule

*NCI Thesaurus Code:  C119701

*Synonyms & Abbreviations:  Hocena

*Definition: 

An orally available capsule containing antroquinonol, a farnesylated quinone derivative isolated from the mycelium of Antrodia camphorata, with potential antineoplastic activity. Upon oral administration, antroquinonol binds to and inhibits protein prenylation mediated by the enzymes farnesyltransferase (FTase) and geranylgeranyltransferase 1 (GGTase-1). This prevents both post-translational prenylation and signaling activity of a number of Ras superfamily proteins, such as Ras and Rho. This results in the inhibition of downstream signaling, such as the PI3K/mTOR signaling pathway, and induces apoptosis in susceptible tumor cells. Ras superfamily proteins are overexpressed in numerous cancer cell types, and play a key role in tumor cell proliferation and survival.

  • Display Name:  Antroquinonol Capsule
  • Label:  Antroquinonol Capsule
  • NCI Thesaurus Code:  C119701 (Search for linked caDSR metadata)   (search value sets)
  • NCI Metathesaurus Link:  CL421596  (see NCI Metathesaurus info)