Anti-cancer related

Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways

PC Chiang, SC Lin, SL Pan, CH Kuo, IL Tsai… – Biochemical …, 2010 – Elsevier

Abstract 5′ AMP-activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are two serine/threonine protein kinases responsible for cellular energy homeostasis and translational control, respectively. Evidence suggests that these two …

[PDF] academia.edu

Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles

VB Kumar, TC Yuan, JW Liou, CJ Yang, PJ Sung… – Mutation Research …, 2011 – Elsevier

Antroquinonol a derivative of Antrodia camphorata has been reported to have antitumor effects against various cancer cells. However, the effect of antroquinonol on cell signalling and survival pathways in non-small cell lung cancer (NSCLC) cells has not been fully …

[PDF] academia.edu

Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles

VB Kumar, TC Yuan, JW Liou, CJ Yang, PJ Sung… – Mutation Research …, 2011 – Elsevier

Antroquinonol a derivative of Antrodia camphorata has been reported to have antitumor effects against various cancer cells. However, the effect of antroquinonol on cell signalling and survival pathways in non-small cell lung cancer (NSCLC) cells has not been fully …

Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells

CC Yu, PC Chiang, PH Lu, MT Kuo, WC Wen… – The Journal of nutritional …, 2012 – Elsevier

Pancreatic cancer is a malignant neoplasm of the pancreas. A mutation and constitutive activation of K-ras occurs in more than 90% of pancreatic adenocarcinomas. A successful approach for the treatment of pancreatic cancers is urgent. Antroquinonol, a ubiquinone …

Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells

CL Ho, JL Wang, CC Lee, HY Cheng, WC Wen… – Biomedicine & …, 2014 – Elsevier

Antroquinonol is the smallest anticancer molecule isolated from Antrodia camphorata thus far. The ubiquinone-like structure of Antroquinonol exhibits a broad spectrum of activity against malignancies in vivo and in vitro. However, the mechanism of action of …

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[HTML] Antroquinonol targets FAK-signaling pathway suppressed cell migration, invasion, and tumor growth of C6 glioma

V Thiyagarajan, MJ Tsai, CF Weng – PLoS One, 2015 – journals.plos.org

Focal adhesion kinase (FAK) is a non-receptor protein tyrosine that is overexpressed in many types of tumors and plays a pivotal role in multiple cell signaling pathways involved in cell survival, migration, and proliferation. This study attempts to determine the effect of …

Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1-and AKT-NF-κB-dependent MMP-9 and epithelial …

WT Lee, TH Lee, CH Cheng, KC Chen, YC Chen… – Food and chemical …, 2015 – Elsevier

Antroquinonol (ANQ) is an ubiquinon derivative isolated from the mycelium of Antrodia camphorata. However, the effect of ANQ on breast cancer treatment is unknown. We found that ANQ significantly suppressed the migration and invasion of breast cancer MDA-MB-231 …

Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular …

HC Lin, MH Lin, JH Liao, TH Wu, TH Lee… – Journal of agricultural …, 2016 – ACS Publications

Antroquinonol (ANQ) is a ubiquinone derivative from the unique mushroom Antrodia camphorata, which exhibits broad-spectrum bioactivities. The effects of ANQ on cancer stem cell-like properties in colon cancer, however, remain unclear. In this study, we found that …

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[HTML] A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment …

YC Lee, CL Ho, WY Kao… – … and clinical oncology, 2015 – spandidos-publications.com

Antroquinonol is isolated from Antrodia camphorata, a camphor tree mushroom, and is a valuable traditional Chinese herbal medicine that exhibits pharmacological activities against several diseases, including cancer. this first‑in-human phase I study of antroquinonol  …

[PDF] researchgate.net

Pharmacological activities of antroquinonol-Mini review

V Angamuthu, M Shanmugavadivu… – Chemico-biological …, 2019 – Elsevier

Antrodia camphorata is an expensive mushroom that grows on the inner cavity of an endangered native tree of Taiwan namely Cinnamomum kanehirai Hayata. It is used as a traditional medicine in Taiwan and has several health benefits including free radical …

Antroquinonol to block Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells.

CL Ho, H Cheng, MCM Chen, DS Ettinger – 2015 – ascopubs.org

e18526 Background: Antroquinonol is the smallest anticancer molecule isolated from Antrodia camphorata thus far. The ubiquinone-like structure of Antroquinonol exhibits a broad spectrum of activity against malignancies in vivo and in vitro. However, the …

Abstract# 3676: Antroquinonol inhibits tumorgenesis and metastasis in highly invasive non-small-cell lung cancer cells

WY Hsieh, HW Chen, SL Yu, WC Wen, SY Liu… – 2009 – AACR

Antrodia camphorata, a parasitic fungus indigenous to Taiwan, has been used as the folk medicine in immuno-regulation and anti-cancer therapies for over six decades. Recently, antroquinonol, an ubiquinone derivative from Antrodia camphorata, has been reported with …

Phase II multicenter study of antroquinonol in patients with stage IV non-small cell lung cancer who have failed at least two lines of anti-cancer therapy.

CL Ho, DS Ettinger, PN Chen, H Cheng, WC Wen… – 2019 – ascopubs.org

e20522 Background: The aim of this study was to assess the efficacy of Antroquinonol in patients with stage IV NSCLC after failure in two-lines of anti-cancer therapy. Methods: Patients with stage IV non-squamous NSCLC who have failed at 2-4 lines of anti-cancer …

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata

TH Lee, CK Lee, WL Tsou, SY Liu, MT Kuo… – Planta …, 2007 – thieme-connect.com

… Antroquinonol (1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan … Thus, 1 was characterized as the shown structure, and named antroquinonol …

Antroquinonol, A Natural Ubiquinone Derivative, Induces Anticancer Activity Against Human Pancreatic Carcinoma Cells Through PI3-kinase/Akt/Mtor Pathways

CC Yu, JH Guh – 2011 …, 2011 – ir.cnu.edu.tw

Pancreatic cancer is a malignant neoplasm of the pancreas. In recent years, the molecular mechanism of pancreatic cancer has been better understood than ever) efore, leading to new approaches of the treatment. Antroquinonol, a ubiquinone derivative isolated from a …

Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1-and AKT-NF-κB-dependent MMP-9 and epithelial …

WT Lee, TH Lee, CH Cheng, KC Chen, YC Chen… – Food and chemical …, 2015 – Elsevier

… Highlights.

  • Antroquinonol (ANQ) effectively inhibits breast cancer migration and invasion.
  • Abstract. Antroquinonol (ANQ) is an ubiquinon derivative isolated from the mycelium of Antrodiac amphorata. However, the effect of ANQ on breast cancer treatment is unknown …

[PDF] academia.edu

Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles

VB Kumar, TC Yuan, JW Liou, CJ Yang, PJ Sung… – Mutation Research …, 2011 – Elsevier

… carcinogenic properties that are gaining attention in the treatment of human cancers, thus offering … effects of A. camphorate in prostate cancer, bladder carcinoma, and breast cancer cells [17 … Previous study has shown that antroquinonol, a major compound found in A. camphorate …

Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular …

HC Lin, MH Lin, JH Liao, TH Wu, TH Lee… – Journal of agricultural …, 2016 – ACS Publications

… for several reasons, including liver protection, hypertension, food detoxification, and cancer prevention … and suppression of a variety of malignancies including bladder, breast, ovarian, and … We previously solated antroquinonol (ANQ), which is the most abundant component from …

[PDF] nutrimaxorganic.com

Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways

PC Chiang, SC Lin, SL Pan, CH Kuo, IL Tsai… – Biochemical …, 2010 – Elsevier

… As for the in vivo efficacy, because the take rate of HepG2 xenografts is limited to less than 30%, we performed the in vivo study using Hep3B derived cancer xenografts. In our unshown data, antroquinonol (50 mg/kg, ip) prolonged the doubling time of the tumor from 4 days to …

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[HTML] Antroquinonol targets FAK-signaling pathway suppressed cell migration, invasion, and tumor growth of C6 glioma

V Thiyagarajan, MJ Tsai, CF Weng – PLoS One, 2015 – journals.plos.org

… growth inhibitory effects of A. camphorate on cancers such as ovarian cancer, breast cancer, bladder carcinoma … Fraction-6) can induce apoptosis of non-small cell lung cancer (NSCLC) cells … Antroquinonol isolated from A. camphorate has been reported to be antitumorigenic on …

Neurodegeneration, Alzheimer’s Disease

[PDF] semanticscholar.org

[PDF] Antroquinonol Lowers Brain Amyloid-β Levels and Improves

WH Chang, MC Chen, IH Cheng – pdfs.semanticscholar.org

Representative synaptophysin images from WT and APP mice with or without antroquinonol treatment.(a) WT mice showed higher synaptophysin intensity at CA3 region of hippocampus (arrow) compared to (b) APP mice.(bd) Antroquinonol consumption revealed a …

[HTML] Antroquinonol lowers brain amyloid-β levels and improves spatial learning and memory in a transgenic mouse model of Alzheimer’s disease

WH Chang, MC Chen, IH Cheng – Scientific reports, 2015 – nature.com

… Increased lipid peroxidation as well as protein and DNA oxidation are found in AD brains 12 , AD cerebrospinal fluid 13 and neurons derived from … 1 and Supplementary Table 1). However, females administered 100 mg/kg/day of antroquinonol had a lower brain weight than …

Auto-immune modulation, anti-inflammation:

[PDF] nchu.edu.tw

Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation

KJS Kumar, FH Chu, HW Hsieh, JW Liao, WH Li… – Journal of …, 2011 – Elsevier

Aim of the study In recent years, the medicinal mushroom Antrodia cinnamomea, known as “niu-chang chih” has received much attention with regard to its possible health benefits; especially its hepatoprotective effects against various drugs, toxins, and alcohol induced …

Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice

PY Tsai, SM Ka, TK Chao, JM Chang, SH Lin… – Free Radical Biology …, 2011 – Elsevier

Oxidative stress, inflammation, and fibrosis are involved in the development and progression
of focal segmental glomerulosclerosis (FSGS), a common form of idiopathic nephrotic
syndrome that represents a therapeutic challenge because it has a poor response to …

[PDF] wiley.comFull View

Antroquinonol differentially modulates T cell activity and reduces interleukin‐18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis

PY Tsai, SM Ka, JM Chang, JH Lai, MS Dai… – Arthritis & …, 2012 – Wiley Online Library

Objective Accelerated severe lupus nephritis (ASLN), with an acute onset of severe clinical manifestations and histopathologic renal lesions, may represent transformation of mild LN to a severe form of glomerulonephritis. Abnormal activation of T and B cells and/or oxidative …

Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 …

SM Yang, SM Ka, KF Hua, TH Wu, YP Chuang… – Free Radical Biology …, 2013 – Elsevier

High levels of reactive oxygen species (ROS), systemic T cell activation, and macrophage infiltration in the kidney are implicated in the acceleration and progression of IgA nephropathy (IgAN), the most frequent type of primary glomerulonephritis. However, the …

[PDF] hindawi.com

Antroquinonol Exerts Immunosuppressive Effect on CD8

C Guan, Q Li, X Song, W Xu, L Li, A Xu – Oxidative Medicine and …, 2017 – hindawi.com

Antroquinonol was investigated as antioxidant and inhibition of inflammatory responses. Our
study was to evaluate its immunosuppressive effect on CD8 + T cells and protective effect on
depigmentation. CD8 + T cells were treated with antroquinonol in vitro, and C57BL/6 mice were …

[HTML] nih.gov

[HTML] Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2

C Guan, Q Li, X Song, W Xu, L Li… – Oxidative medicine and …, 2017 – ncbi.nlm.nih.gov

Antroquinonol was investigated as antioxidant and inhibition of inflammatory responses. Our study was to evaluate its immunosuppressive effect on CD8+ T cells and protective effect on depigmentation. CD8+ T cells were treated with antroquinonol in vitro, and C57BL/6 mice …

An extract of Antrodia camphorata mycelia attenuates the progression of nephritis in systemic lupus erythematosus-prone NZB/W F1 mice

JM Chang, YR Lee, LM Hung, SY Liu… – Evidence-Based …, 2011 – hindawi.com

… Antroquinonol, an active component of ACE, was investigated for anti-inflammation
activity in lipopolysaccharide-induced RAW 267.4 cells … The thickness was measured
using a microscope. 3.5. Anti-Inflammation of Antroquinonol …

Antroquinonol Exerts Immunosuppressive Effect on [CD8. sup.+] T Cell Proliferation and Activation to Resist Depigmentation Induced by [H. sub. 2][O. sub. 2].

C Guan, Q Li, X Song, W Xu, L Li, A Xu – Oxidative Medicine and …, 2018 – go.gale.com

Antroquinonol was investigated as antioxidant and inhibition of inflammatory responses. Our study was to evaluate its immunosuppressive effect on [CD8. sup.+] T cells and protective effect on depigmentation.[CD8. sup.+] T cells were treated with antroquinonol in vitro, and …

Metabolic

[PDF] wiley.comFull View

Synthetic (+)‐antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities

CY Hsu, RS Sulake, PK Huang, HY Shih… – British journal of …, 2015 – Wiley Online Library

Background and Purpose The fungal product (+)‐antroquinonol activates AMP kinase (AMPK) activity in cancer cell lines. The present study was conducted to examine whether chemically synthesized (+)‐antroquinonol exhibited beneficial metabolic effects in insulin …

Antroquinonol Attenuated Abdominal and Hepatic Fat Accumulation in Rats Fed an Obesogenic Diet

JR Chen, WJ Yeh, HY Tan, HY Yang – Journal of food science, 2019 – Wiley Online Library

An imbalance of energy intake and expenditure leads to fat accumulation and metabolic disorders. The aim of the study was to investigate the effects of antroquinonol on diet‐ induced obesity. Thirty‐two rats were divided into a control group (C), an obesogenic group …

Renoprotective effects of antroquinonol in rats with Nω-nitro-L-arginine methyl ester-induced hypertension

JR Chen, J Ko, WJ Yeh, WC Huang, HY Yang – Nutrients, 2018 – mdpi.com

Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water …

[PDF] semanticscholar.org

[PDF] Effects of Antrodia Camphorata Mycelia Extract Containing Antroquinonol on Lowering Low-Density Lipoprotein Cholesterol: A Randomized Double-Blind …

MCM Chena, PN Chena… – … of Pharmacy and …, 2017 – pdfs.semanticscholar.org

Objective: Antrodia camphorata is a type of true fungus that grows only on Cinnamomum camphora trees, also known as Cinnamomum kanehirae (“kashi”) in Taiwan. Antroquinonol is a characteristic component of A. camphorata mycelia extract and was previously shown to …

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[HTML] Antroquinonol, an active pure compound from Antrodia camphorate mycelium, modulates the development of atherosclerosis in a mouse carotid artery …

TJ Lin, YY Lee, BH Tzeng, SP Yang… – Journal of Medical …, 2014 – jpgmonline.com

Background: Antroquinonol (Antroq) is an active component of Antrodia camphorate. The present study was to validate the preventive effects of Antroq in an atherosclerosis model. Materials and Methods: We examined Antroq inhibitory effect on rat aortic smooth muscle …

[PDF] wiley.comFull View

Synthetic (+)‐antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities

CY Hsu, RS Sulake, PK Huang, HY Shih… – British journal of …, 2015 – Wiley Online Library… This isomer (hereafter referred to as antroquinonol) has shown anti‐cancer potential in human hepatocellular carcinoma cells (Chiang et al., 2010), pancreatic carcinoma cells (Yu et al., 2012a), non‐small cell lung cancer (Kumar et al., 2011), breast carcinoma and prostate …

[PDF] Effects of Antrodia Camphorata Mycelia Extract Containing Antroquinonol on Lowering Low-Density Lipoprotein Cholesterol: A Randomized Double-Blind …

MCM Chena, PN Chena… – … of Pharmacy and …, 2017 – pdfs.semanticscholar.org… Therefore, we conducted a randomized double-blind study to assess the ability of A. camphorata mycelia extract to lower LDL cholesterol and total cholesterol in individuals with somewhat high levels of LDL cholesterol … Antroquinonol Lowers Brain Amyloid-β Levels …

Anti-fatigue, liver protection

[HTML] The Anti-exhaustive Effects of Antroquinonol in Tennis Player

The 9th Annual Conference for SCSEPF, 2010 – ir.lib.ypu.edu.tw

Antrodia camphorata (Niu-chang-chih) is a local fungi specie found in Taiwan. It seems to only grow on elder Niu-chang tree (Cinnamomum Kanehirai Hay). Its fruit body has been used as Chinese herb in treatment of various diseases. and it has been shown to exhibit …

The effects of Antroquinonol supplementation on physiological responses after exhaustive tennis groundstrokes.

 The 9th Annual Conference for SCSEPF, 2010 – ir.lib.ypu.edu.tw

  • Purpose: The purpose of this study was to investigate the effects of Antroquinonol (A) supplementation on physiological responses after exhaustive tennis groundstrokes.
  • Methods: Twelve university tennis club male health subjects participated in the study. The …

Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation

KJS Kumar, FH Chu, HW Hsieh, JW Liao, WH Li… – Journal of …, 2011 – Elsevier

… Livers were harvested, formalin fixed, and stained with hematoxylin-eosin for evaluation of … In humans, acute or chronic alcohol ingestion results in alcoholic liver diseases that are …Antroquinonol, a ubiquinone derivative isolated from the mycelia of Antrodia cinnamomea showed …

Synthesis

Total synthesis of (+)-antroquinonol and (+)-antroquinonol D

RS Sulake, C Chen – Organic letters, 2015 – ACS Publications

The first total synthesis of (+)-antroquinonol and (+)-antroquinonol D, two structurally unique quinonols with a sesquiterpene side chain, is described. The route features an iridium- catalyzed olefin isomerization–Claisen rearrangement reaction (ICR), lactonization, and …

Enabling the biosynthesis of antroquinonol in submerged fermentation of Antrodia camphorata

YD Hu, H Zhang, RQ Lu, XR Liao, BB Zhang… – Biochemical engineering …, 2014 – Elsevier

In recent years, Antroquinonol has been considered as one of the most potent bioactive components in the medicinal mushroom Antrodia camphorata. However, Antroquinonol could not be produced via conventional submerged fermentation of A. camphorata. In this …

Synthesis of (+)-antroquinonol: an antihyperglycemic agent

RS Sulake, HH Lin, CY Hsu, CF Weng… – The Journal of organic …, 2015 – ACS Publications

The total synthesis of antroquinonol has been accomplished through Suzuki–Miyaura cross- coupling and Barton–McCombie reaction, and the α, β-unsaturation was achieved through selenylation and oxidation protocols. In vitro and in vivo studies on the glucose-lowering …

[PDF] rsc.org

A short synthesis of (±)-antroquinonol in an unusual scaffold of 4-hydroxy-2-cyclohexenone

CS Hsu, HH Chou, JM Fang – Organic & biomolecular chemistry, 2015 – pubs.rsc.org

Antroquinonol, which was first isolated from a mushroom, Antrodia cinnamomea, found in Taiwan, is an anticancer compound with a unique core structure of 4-hydroxy-2, 3- dimethoxycyclohex-2-enone carrying methyl, farnesyl and hydroxyl substituents in the 4, 5 …

A mechanistic study on the biosynthetic regulation of bioactive metabolite antroquinonol from edible and medicinal mushroom Antrodia camphorata

YD Hu, BB Zhang, GR Xu, XR Liao… – Journal of Functional …, 2016 – Elsevier

Antroquinonol, an important bioactive metabolite from the edible mushroom Antrodia camphorata, was difficult to be synthesised by conventional submerged fermentation. The present study revealed the mechanisms related to the stimulatory effect of coenzyme Q 0 …

Metabolites of antroquinonol found in rat urine following oral administration

CK Chen, JJ Kang, WC Wen, HF Chiang… – Journal of natural …, 2014 – ACS Publications

Four metabolites (1–4) of antroquinonol from rat urine, collected within 24 h after oral administration of antroquinonol, were characterized by HPLC–SPE–NMR. Compounds 1–4 were further isolated by semipreparative HPLC for structure confirmation. Their structures …

Induction of antroquinonol production by addition of hydrogen peroxide in the fermentation of Antrodia camphorata S‐29

Y Xia, X Zhou, G Wang, B Zhang… – Journal of the Science …, 2017 – Wiley Online Library

BACKGROUND Antroquinonol have significantly anti‐tumour effects on various cancer cells. There is still lack of reports on regulation of environmental factors on antroquinonol production by Antrodia camphorata. RESULTS An effective submerged fermentation method …

Synthesis of (+)‐Antroquinonol and Analogues by Using Enantioselective Michael Reactions of Benzoquinone Monoketals

CS Hsu, JM Fang – European Journal of Organic Chemistry, 2016 – Wiley Online Library

(+)‐Antroquinonol is an anticancer agent that was first isolated from the rare mushroom Antrodia cinnamomea, which is indigenous to Taiwan. In this study,(+)‐antroquinonol is synthesized from benzoquinone monoketals by using an enantioselective Michael reaction …

  Total synthesis of (±)-antroquinonol

X Wang, C Du, B Hong, X Lei – Organic & biomolecular chemistry, 2019 – pubs.rsc.org

We report the total synthesis of (±)-antroquinonol based on a concise and efficient route. Key features include two different strategies to install the required three contiguous stereogenic centers, which not only furnish the desired natural product but also provide natural product …

Recovery and Purification of Antroquinonol from Antrodia camphorata Fermentation Products

R LU, B ZHANG, G XU – Journal of Food Science and …, 2016 – en.cnki.com.cn

This paper discusses the antroquinonol purification process, the response surface method was used to extract more antroquinonol, and silica gel column chromatography to obtain high purity of antroquinonol. The experimental results show that the optimal conditions for …

Research of A. camphorata solid-state fermentation production Antroquinonol and extraction Antroquinonl

X YU, Y XIA, H ZHANG, G XU… – Science and Technology of …, 2013 – en.cnki.com.cn

Antroquinonol, a metabolite produced from solid-state fermentation of Antrodia camphorata has been shown great anti-cancer effect. This study investigated the effects of a number of factors including fermented grain types, substrate capacity, initial moisture content …

4-Hydroxybenzoic acid serves as an endogenous ring precursor for antroquinonol biosynthesis in Antrodia cinnamomea

KCC Chou, HL Wu, PY Lin, SH Yang, TL Chang… – Phytochemistry, 2019 – Elsevier

Antrodia cinnamomea, an endemic fungus species of Taiwan, has long been used as a luxurious dietary supplement to enhance liver functions and as a remedy for various cancers. Antroquinonol (AQ), identified from the mycelium of A. cinnamomea, is currently in …  

An approach toward novel bioactive natural products antroquinonols: de novo construction of the carbocyclic core

NR Modugu, G Mehta – Tetrahedron Letters, 2015 – Elsevier

… 2 However, a significant advance was made in 2007 when a group from Taiwan reported 2a the isolation of a novel 4-hydroxycyclohex-2-enone based natural product antroquinonol 1, reminiscent of ubiquinone (Q10) architecture, from the solid state cultured mycelia of A …

Induction of antroquinonol production by addition of hydrogen peroxide in the fermentation of Antrodia camphorata S‐29

Y Xia, X Zhou, G Wang, B Zhang… – Journal of the Science …, 2017 – Wiley Online Library

… inhibition of protein isoprenyl transferase activity in cancer cells. Furthermore, antroquinonol can lower brain amyloid‐β levels and improves spatial learning and memory in a transgenic mouse model of Alzheimer’s disease.13 …